CAR T design and CAR-T

CAR T design and CAR-T

0 0 hace 2 años
Numerous preclinical studies of CAR-T cell therapy have demonstrated that the CAR T design of single-chain variable domains, the length and composition of extracellular hinge regions, and the selection of intracellular co-stimulatory molecular sequences as a model system for CAR produce a very important influence on the clinical effect of CAR T. Current relevant clinical trials have shown that CAR-T containing a CD28 or 4-1BB co-stimulatory molecular structure is more efficient than CAR-T alone ... Más informaciones

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